Helicity Dependent Directional Surface Plasmon Polariton Excitation Using A Metasurface with Interfacial Phase Discontinuity

Surface plasmon polaritons (SPPs) have been widely exploited in various scientific communities, ranging from physics, chemistry to biology, due to the strong confinement of light to the metal surface. For many applications it is important that the free space photon can be coupled to SPPs in a controllable manner. In this Letter, we apply the concept of interfacial phase discontinuity for circularly polarizations on a metasurface to the design of a novel type of polarization dependent SPP unidirectional excitation at normal incidence. Selective unidirectional excitation of SPPs along opposite directions is experimentally demonstrated at optical frequencies by simply switching the helicity of the incident light. This approach, in conjunction with dynamic polarization modulation techniques, opens gateway towards integrated plasmonic circuits with electrically reconfigurable functionalities.Comment: 17 pages, 5 figures. Published on <Light:Science & Applications

Towards using concurrent Java API correctly

Concurrent Programs are hard to analyze or debug due to the complex program logic and unpredictable execution environment. In practice, ordinary programmers often adopt existing well-designed concurrency related API (e.g., those in java.util.concurrent) so as to avoid dealing with these issues. These API can however often be used incorrectly, which results in hardto-debug concurrent bugs. In this work, we propose an approach for enforcing the correct usage of concurrency-related Java API. Our idea is to annotate concurrency-related Java classes with annotations related to misuse of these API and develop lightweight type checker to detect concurrent API misuse based on the annotations. To automate this process, we need to solve two problems: (1) how do we obtain annotations of the relevant API; and (2) how do we systematically detect concurrent API misuse based on the annotations? We solve the first problem by extracting annotations from the API documentation using natural language processing techniques. We solve the second problem by implementing our type checkers in the Checker Framework to detect concurrent API misuse. We apply our approach to extract annotations for all classes in the Java standard library and use them to detect concurrent API misuse in open source projects on GitHub. We confirm that concurrent API misuse is common and often results in bugs or inefficiency.No Full Tex

M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes.

Acute injury in the setting of liver fibrosis is an interesting and still unsettled issue. Most recently, several prominent studies have indicated the favourable effects of liver fibrosis against acute insults. Nevertheless, the underlying mechanisms governing this hepatoprotection remain obscure. In the present study, we hypothesized that macrophages and their M1/M2 activation critically involve in the hepatoprotection conferred by liver fibrosis. Our findings demonstrated that liver fibrosis manifested a beneficial role for host survival and apoptosis resistance. Hepatoprotection in the fibrotic liver was tightly related to innate immune tolerance. Macrophages undertook crucial but divergent roles in homeostasis and fibrosis: depleting macrophages in control mice protected from acute insult; conversely, depleting macrophages in fibrotic liver weakened the hepatoprotection and gave rise to exacerbated liver injury upon insult. The contradictory effects of macrophages can be ascribed, to a great extent, to the heterogeneity in macrophage activation. Macrophages in fibrotic mice exhibited M2-preponderant activation, which was not the case in acutely injured liver. Adoptive transfer of M2-like macrophages conferred control mice conspicuous protection against insult. In vitro, M2-polarized macrophages protected hepatocytes against apoptosis. Together, M2-like macrophages in fibrotic liver exert the protective effects against lethal insults through conferring apoptosis resistance to hepatocytes

Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2*

Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited cause of kidney failure, is caused by mutations in either PKD1 (85%) or PKD2 (15%). The PKD2 protein, polycystin-2 (PC2 or TRPP2), is a member of the transient receptor potential (TRP) superfamily and functions as a non-selective calcium channel. PC2 has been found to form oligomers in native tissues suggesting that it may form functional homo- or heterotetramers with other subunits, similar to other TRP channels. Our experiments unexpectedly revealed that PC2 mutant proteins lacking the known C-terminal dimerization domain were still able to form oligomers and co-immunoprecipitate full-length PC2, implying the possible existence of a proximal dimerization domain. Using yeast two-hybrid and biochemical assays, we have mapped an alternative dimerization domain to the N terminus of PC2 (NT2-1-223, L224X). Functional characterization of this domain demonstrated that it was sufficient to induce cyst formation in zebrafish embryos and inhibit PC2 surface currents in mIMCD3 cells probably by a dominant-negative mechanism. In summary, we propose a model for PC2 assembly as a functional tetramer which depends on both C- and N-terminal dimerization domains. These results have significant implications for our understanding of PC2 function and disease pathogenesis in ADPKD and provide a new strategy for studying PC2 function

Services Liberalization and Export Diversity: Theory and Evidence from Chinese Firms

During the last decades, we observe a liberalization trend in the services sector globally. Using the Chinese exporting firm data, this paper studies how multi-product firms adjust their export strategies in response to the services trade liberalization across export destination countries. Our study finds a highly significant positive relation between the services trade liberalization in the destination countries and each firm's export diversify, which is measured as the product scope, the Herfindahl-Hirschman style index, or the value skewness across varieties,export product switch. Our empirical analysis further finds that firms increase the relatedness of their exporting varieties towards the OECD countries, but reduce it towards the non-OECD countries. With a conventional multi-product firm model, we explore the mechanisms behind all our empirical findings

Services Liberalization and Export Diversity: Theory and Evidence from Chinese Firms

During the last decades, we observe a liberalization trend in the services sector globally. Using the Chinese exporting firm data, this paper studies how multi-product firms adjust their export strategies in response to the services trade liberalization across export destination countries. Our study finds a highly significant positive relation between the services trade liberalization in the destination countries and each firm's export diversify, which is measured as the product scope, the Herfindahl-Hirschman style index, or the value skewness across varieties,export product switch. Our empirical analysis further finds that firms increase the relatedness of their exporting varieties towards the OECD countries, but reduce it towards the non-OECD countries. With a conventional multi-product firm model, we explore the mechanisms behind all our empirical findings